Meriwether Lewis and William Clark formed the Corps of Discovery for the first time in Clarksville, Indiana, in October of 1803.  Lewis prepared for the expedition for many months, and on August 31, 1803, left Pittsburgh, Pennsylvania traveling down the Ohio River to Clarksville.  There, Lewis would join forces with Clark who was staying with his brother, Revolutionary War General George Rogers Clark, in the General's log cabin overlooking the Falls of the Ohio. Historian and author, the late Stephen Ambrose, memorialized the meeting in his book, Undaunted Courage, when he penned the phrase, "When they shook hands, the Lewis and Clark Expedition began."  Today that handshake is captured in a life-size statue in front of the Interpretive Center at the Falls of the Ohio State Park.