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Multidrug-Resistant Pseudomonas aeruginosa (MDR-PA)

What is Multidrug-Resistant Pseudomonas aeruginosa (MDR-PA)?

Pseudomonas is a genus of gram-negative bacteria found normally in the environment. Pseudomonas aeruginosa is the most common strain that causes infections in humans. Around 13% of P. aeruginosa infections are multidrug-resistant (MDR-PA). Mild infections, such as ear infections and rashes, can occur among healthy people, but serious infections typically occur in seriously ill patients. People who are at greatest risk for P. aeruginosa infection include those using medical devices such as breathing machines and catheters. Patients with surgical or burn wounds are also at a greater risk for P. aeruginosa infection. P. aeruginosa can be transmitted though the hands of healthcare workers and contaminated equipment.

Carbapenem-Resistant Pseudomonas aeruginosa (CRPA)

Pseudomonas aeruginosa infections can also be carbapenem resistant. Between 2-3% of all CRPA  isolates produce a carbapenemase enzyme. Similar to other carbapenemase producing organisms (CP-CRE and CRAB), the genetic elements that code for carbapenemase production are mobile and can be horizontally transferred to other bacteria.

  • Containment Strategy

    The Center for Disease Control and Prevention's (CDC's) containment strategy can be use for rapid detection and response to novel and targeted organisms. Healthcare facilities and public health departments can work together to detect and contain these organisms. These strategies can be used in collaboration with other containment and response activities to enhance detection.

    Containment Strategy:

    • Rapid Identification
    • Infection Control Assessments
    • Colonization Screenings (when needed)
    • Coordinated Response between Facilities
    • Continue assessments and screenings until spread is controlled
  • Water Management

    Pseudomonas aeruginosa is often found in water and soil. Healthcare facilities should have a water management plan in order to reduce the risk of infections from organisms commonly found in water that may cause infections. Other oppurtunistic pathogens include Stenotrophomonas matlophilia, Nontuberculosis mycobacteria, and Legionella.

    Potential Transmission Routes from Water to Patiens

    Source: CDC

Reviewed and Updated: April 2022