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Indiana State Department of Health

Genomics Program Home > For Professionals > Cystic Fibrosis Educational Information Cystic Fibrosis Educational Information

How is Cystic Fibrosis (CF) Newborn Screening performed?

In October 2007, the State of Indiana added cystic fibrosis (CF) to its newborn screening panel. In Indiana, CF newborn screening is a two-step process performed on a standard Guthrie card. The first step involves analysis of immunoreactive trypsin (IRT). Specimens that have IRT levels in the top 4% are considered abnormal; these specimens are then automatically sent for a second test that checks for mutations within the CFTR gene.  Indiana's CF newborn screening looks for 43 of the most common CFTR gene changes. 

The screen is considered “positive” for CF if one or more mutations from the panel are detected. At this step, the healthcare practitioner is notified of the positive test by the Indiana University Newborn Screening Laboratory.

Click here to view “Cystic Fibrosis: A Review for Healthcare Providers."

Click here to download the Physician Reporting Form.

Click here for a list of resources for families of children with newborn screening conditions.

Information for Families 
(Click on the name of an information sheet to download.)
Physician Information
(Click on the name of an information sheet to download.)
Overview of Cystic Fibrosis Newborn Screening (en español) Overview of Cystic Fibrosis Newborn Screening for Healthcare Providers
Newborn Screen Positive for One Gene Change (en español) Action Sheet for Healthcare Providers
Newborn Screen Positive for Two Gene Changes (en español) Contact Information for CFF-accredited centers in Indiana
Instruction Sheets for Sweat Test Laboratories Why Use CF Foundation-Accredited Centers?
  Deaconess Hospital (en español) Contact Information for Indiana’s Genetic Services Providers (en español)
  Lutheran Hospital (en español) South Bend Medical Foundation Laboratory locations 

**Please note that the ONLY accredited sweat testing laboratory for St. Joseph Regional Medical Center is located 530 N. Lafayette Boulevard in South Bend. No other South Bend Medical Foundation location is accredited to collect sweat tests.**

  Riley Hospital  (en español) Cystic Fibrosis Video for Families
  St. Joseph Regional Medical Center, South Bend (en español)  
Children’s Special Health Care Services (CSHCS) Fact Sheet