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The Strategic Prevention Framework State Incentive Grant (SPF SIG) is a five year cooperative agreement from the Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention (SAMHSA/CSAP) awarded to the Office of the Governor to reduce substance use and abuse across the lifespan of Indiana citizens. The vision of the SPF SIG is to Imagine Indiana Together-with a network of grassroots organizations collaborating to develop 'healthy, safe, and drug-free environments that nurture and assist all Indiana citizens to thrive.' With the administration of the initiative being awarded to the Division of Mental Health and Addiction (DMHA), a five year cooperative agreement involving assessment, capacity building, strategic planning, implementation and evaluation has begun. In creating a solid foundation for the SPF SIG, an Advisory Council, appointed by the Governor, was organized as well as a State Epidemiological Outcomes Workgroup (SEOW). The Governor's Advisory Council (GAC) was established to advise and assist in implementing the strategic planning process as required by CSAP. The focus of the SEOW is to collect and analyze data which indicates the focus for priorities to write an RFS, provide core support to the GAC for prevention decision making and provide systematic and analytical data to support recommendations of priorities for the project. This Strategic Work plan is organized in such a manor as to address, in sequence the requirements of building a cohesive plan which delineates the comprehensive assessment process, a review of the systems (capacity and infrastructure), the priorities, the planning and allocation process, cultural competency, sustainability, implementation and the evaluation of the SPF SIG project.